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These ganglion cell extensions converge at the optic disc, also referred to as the optic papilla, giving rise to the optic nerve head, which contains approximately 1.2 million RGC axons [387]

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In other prevalent neurodegenerative disorders such as mild cognitive impairment or Alzheimer's disease, where reduced brain glucose metabolism has been shown to precede the onset of cognitive symptoms (Cunnane et al., 2020), further investigations are needed to determine brain NAD status