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The structural unit of these transporters is composed of a transmembrane domain (TMD) that binds substrates and a nucleotide binding domain (NBD) for ATP hydrolysis

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376 Similarly, neuroactive metabolites such as gamma-aminobutyric acid and short-chain fatty acids, produced by the gut microbiota, modulate brain function and emotional regulation, illustrating the metabolic cross-talk within the gut–brain axis